Somatic Causes Were Omitted

Somatic Activation of AKT3 Causes Hemispheric Developmental Brain Malformations

Hemimegalencephaly (HMG) is a developmental brain disorder characterized by an enlarged, malformed cerebral hemisphere, typically causing epilepsy that requires surgical resection. We studied resected HMG tissue to test whether the condition might reflect somatic mutations affecting genes critical to brain development. We found that two out of eight HMG samples showed trisomy of chromosome 1q, ...

Somatic HRAS p.G12S Mutation Causes Woolly Hair and Epidermal Nevi

Loss of centrioles causes chromosomal instability in vertebrate somatic cells

Most animal cells contain a centrosome, which comprises a pair of centrioles surrounded by an ordered pericentriolar matrix (PCM). Although the role of this organelle in organizing the mitotic spindle poles is well established, its precise contribution to cell division and cell survival remains a subject of debate. By genetically ablating key components of centriole biogenesis in chicken DT40 B...

Dynamic Psychological Games: Omitted Material

This manuscript collects proofs and other material omitted from Dynamic Psychological Games, mimeo, November 2007 (DPG). To make it more self-contained, key de…nitions and results of the main paper are included. For the convenience of readers of DPG, the numbers of equations and statements coincide with DPG. 1 Extensive forms with observable actions Here we provide a more complete de…nition of ...

Outcome measurement in functional somatic syndromes: SF-36 summary scores and some scales were not valid.

OBJECTIVE This study aimed to test the validity of the 36-item Short-Form Health Survey (SF-36) scales and summaries in patients with severe functional somatic syndromes (FSS), such as fibromyalgia and irritable bowel syndrome. STUDY DESIGN AND SETTING One hundred twenty patients with severe FSS enrolled in a randomized controlled trial filled in the SF-36 questionnaire. We tested for data qu...